Phytochemical, Pharmacological, and Toxicological Studies on Peganum harmala L.: An Overview of the Last Decade

Objective: Plants have been used to treat ailments since the dawn of humanity. The use medicinal plants for various purposes such as preventing diseases, treating diseases and supporting medical treatment is increasing day by day. On other hand, are important sources raw materials pharmaceutical industry. It has demonstrated that Peganum harmala L. phytochemicals it contains a wide variety pharmacological activities. P. its active ingredients can be an resource In this review, phytochemistry, effects, clinical studies, toxicity discussed under current information. 
 Methods: Studies on were searched using Pubmed, Scopus, Science Direct databases, Google Scholar search engine. As result searches, 96 articles included in study. Results: main group secondary metabolites responsible biological activities alkaloids. plant isolated compounds shown many actions, counting antiamnestic, anticancer, antidepressant, antiinflammatory, cardiovascular, gastroprotective, hepatoprotective, nephroprotective, vasodilator evaluating plant's effects carried out recent years. However, recorded literature causes poisoning with symptoms neurosensory symptoms, visual hallucination, bradycardia, hypotension, agitation, tremor, ataxia, vomiting. Conclusion: Considering number studies efficacy safety should increased.